Intestinal differences among developing and developed countries

People in developed nations generally have low diarrheal episodes due to fecal contamination than those of poorer nations due clean water and better sanitation.

Interestingly this causes repeated attacks by enteric pathogens (microorganisms that commonly cause gut infection) related to faecal contamination in those living in countries vulnerable to poorer sanitation and hygiene. Such repeated infection changes the lining of the gut and leads to malabsorption related problem often known as tropical enteropathy. This condition causes alteration of immune system compromising with the functioning of oral vaccines’ and might cause oral vaccine failure (like cholera vaccine or rotavirus vaccine).

Till date, not much is available to deal with tropical sprue, although improving sanitary situations might be a good option to prevent the problem happening in future.