Why insulin requirement decreases in diabetes patients with long term kidney disease?

Those people who are suffering from diabetes and taking insulin probably become happy when their doctor decreases their dose of insulin or stops insulin.

But if a person is suffering from chronic kidney disease along with diabetes, decrease in insulin doses may not be something to be happy.

When chronic kidney disease deteriorates i.e. progresses to advanced stages, the requirement of insulin falls in diabetics.

Now the question is:

Why insulin requirement falls in advanced stages of chronic kidney disease?

Answer:

  • In advanced stages of chronic renal failure, the kidneys excretion capacity of insulin molecules decrease, therefore more of the insulin remains in blood. Unless the insulin gets excreted normally the further requirement of insulin is less. In such scenario your doctor might decrease your insulin doses.

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