In a suspected case of bacterial meningitis, will it be of worth to do Lumber puncture to see the CSF glucose levels, if the patient has already received 50 ml of 50% glucose ?

The answer is yes, unless its many hours late after the patient had received 50 ml of 50% glucoseand no other contraindication to lumber puncture exists.

In a suspected case of bacterial meningitis CSF glucose levels are generally low.

So one might think that if a patient has already received glucose infusion at presentation to the emergency department, then it will affect the CSF glucose levels.

However, it’s interesting to know that serum glucose levels don’t immediately change the CSF glucose levels. It takes few hours for serum glucose levels to reach the CSF so it may not be too late to do the CSF glucose studies.

In bacterial meningitis CSF glucose levels drop to less than 40 mg/dL. Few other conditions like fungal or tubercular meningitis too can reflect a fall in glucose levels in CSF.

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